Characterization of tolloid-mediated cleavage of the GDF8 procomplex
نویسندگان
چکیده
منابع مشابه
Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation.
Growth differentiation factor 8 (GDF8)/myostatin is a latent TGF-β family member that potently inhibits skeletal muscle growth. Here, we compared the conformation and dynamics of precursor, latent, and Tolloid-cleaved GDF8 pro-complexes to understand structural mechanisms underlying latency and activation of GDF8. Negative stain electron microscopy (EM) of precursor and latent pro-complexes rev...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2021
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bcj20210054